There is now a pressing need to derive novel antibiotics to deal with the multiply
antibiotic resistant stains that now represent significant clinical threats.
The Aberystwyth Natural Products Grouping is responding to this challenge by
mining relatively unexplored part of the natural world for novel drug leads. These
include invasive weeds which survive and thrive in alien environments by
combating native plant species, climate, disease and soil microbes. Their invasive
nature partially arises from a rich and diverse biochemistry which include
clinically-relevant metabolites. Our focus is on bioactive compounds from
Himalayan Balsam and Japanese Knotweed.
We also examine microbes derived from extreme environments which offer
excellent opportunities for drug discovery, owing both to the intrinsic novelty as
they compete for the spare resources typical of these habitats. Our focus is on
microbes isolated from cryconite holes in glaciers and the organic crusts of
Kalahari desert samples.
Our work exploits a well-established discovery pipeline (see below) where
biochemicals are efficiently isolated (using a cutting edge Biotage 4 purification
system), assessed for inhibitory effects on bacteria growth curves (based on E coli,
Pseudomonas aeruginosa, Staphlococcus aureus and Bacillus cereus) and identified
by high resolution Mass Spectrometry or Nuclear Magnetic Resonance.
We welcome enquires via [email protected] or by contacting Prof. Luis Mur
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